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September 1976

Pyoderma Gangrenosum Associated With Active Chronic Hepatitis: Report of Two Cases

Author Affiliations

From the North Staffordshire Hospital Centre, Stoke-on-Trent, England (Drs Byrne and Summerly), and the Cornwall and Isles of Scilly Area Health Authority (Dr Hewitt).

Arch Dermatol. 1976;112(9):1297-1301. doi:10.1001/archderm.1976.01630330059017

• In two patients, active chronic hepatitis was complicated by the development of pyoderma gangrenosum. The favorable response of the pyodermatous lesions to azathioprine therapy suggests that this drug may be of value in treating this disorder in patients for whom corticosteroid therapy produces no benefit or is contraindicated because of side effects. Azathioprine, too, is a potentially toxic drug and may need to be discontinued. Possible causal relationships between pyoderma gangrenosum and active chronic hepatitis are discussed.

(Arch Dermatol 112:1297-1301, 1976)

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