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September 1976

Transfer Factor as Therapeutic Agent in Mycosis Fungoides

Author Affiliations

Aarhus, Denmark

Arch Dermatol. 1976;112(9):1324-1326. doi:10.1001/archderm.1976.01630330078031

To the Editor.—  Within recent years, transfer factor (TF) has been given to a number of patients with immunodeficiency diseases. Lately, TF has also been used to intensify cell-mediated immunity in patients with relative immunological defects.1-3 Although mycosis fungoides seems to be a T cell lymphoma, a number of patients with this disease show a reduced ability to develop cellular immunity.4 We therefore found it reasonable to try TF in addition to other therapeutic measures in a patient who did not respond to conventional treatment with mechlorethamine hydrochloride, methotrexate, or grenz rays alone.

Report of a Case.—  A 64-year-old man had a 1½-year history of general itching and appearance of scaly erythematous plaques and tumors located at the elbows (Fig 1) and the gluteal area. Within two months, he developed heavy keratotic infiltrations of the palms (Fig 2) and soles with many fissures (Fig 3), together with a

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