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October 1976

Hepatitis and Bone Destruction as Uncommon Manifestations of Early Syphilis: Report of a Case

Author Affiliations

From the Department of Diagnostic Radiology, Mayo Clinic, Rochester, Minn (Dr Longstreth), the Dermatology Service, US Public Health Service Hospital, San Francisco (Dr Hoke), and the Department of Medicine, University of California, Los Angeles (Dr Mc Elroy).

Arch Dermatol. 1976;112(10):1451-1454. doi:10.1001/archderm.1976.01630340069020

We describe a patient with a painful lytic lesion of the clavicle and a granuloma of the liver in late secondary syphilis. The classic "moth-eaten" alopecia of the scalp as well as eyebrows and eyelashes suggested syphilis, although an initial false-negative VDRL test for syphilis (prozone phenomenon) caused a delay in diagnosis. Bone as well as liver involvement in early syphilis may be more common than previously recognized.

(Arch Dermatol 112:1451-1454, 1976)

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