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October 1976

Gold Compounds vs Corticosteroids in the Treatment of Pemphigus Vulgaris-Reply

Arch Dermatol. 1976;112(10):1467-1468. doi:10.1001/archderm.1976.01630340079027

—In no way do my remarks contradict my article. However, for clarification, based on the original data from the retrospective study of 49 patients with pemphigus vulgaris, 87% of them did have at least one twomonth period during their treatment in which they required no corticosteroid therapy and were free of lesions. Some of these cases were extremely mild in severity, and this period, however, was often before definitive corticosteroid treatment was begun but after the clinical diagnosis of pemphigus vulgaris was made. Only 18 of the 49 patients achieved remission after definitive corticosteroid therapy was begun, eg, a two-month period in which they were free of lesions and without corticosteroid therapy at some time during their lifetime. Only three of these 18 received adjuvant therapy with cyclophosphamide; the others received corticosteroid therapy alone.

The practicing physician should understand that gold therapy requires repeated injections, and even the minor reactions

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