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We agree with Dr Burnham regarding the morphologic variation of the particulate patterns. The term "speckled" has been used traditionally for the particulate nonhomogeneous patterns. The distinction between the different patterns of particulate staining is difficult on tissue substrates. However, when using a substrate similar to the one Dr Burnham uses in which tissue culture cells are fixed to slides, it is apparent that several different particulate or "speckle-like" patterns are indeed present. Dr Burnham's observations on the morphologic variations of the particulate patterns and their relationship to specific antibodies in certain connective tissue diseases is fascinating and certainly deserves further investigation.
Prystowsky SD, Gilliam JN. Gold Compounds vs Corticosteroids in the Treatment of Pemphigus Vulgaris-Reply to Dr Burnham. Arch Dermatol. 1976;112(10):1468. doi:10.1001/archderm.1976.01630340080028
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