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November 1976

Induction of Glycosuria and Hyperglycemia by Topical Corticosteroid Therapy

Author Affiliations

From the Departments of Dermatology and Pathology, Mount Sinai Medical Center, Miami Beach, Fla.

Arch Dermatol. 1976;112(11):1559-1562. doi:10.1001/archderm.1976.01630350035009

• A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion. A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%. Two additional patients with mildly abnormal responses to glucose tolerance tests showed no evidence of altered glucose metabolism when treated with halcinonide cream in a similar manner.

(Arch Dermatol 112:1559-1562, 1976)