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November 1976

Malignant Atrophic Papulosis of Degos: Report of a Patient Who Failed to Respond to Fibrinolytic Therapy

Author Affiliations

From the departments of dermatology (Drs Howsden, Hodge, Herndon, and Freeman) and pathology (Drs Howsden, Hodge, and Freeman), University of Texas Southwestern Medical School, Dallas. Dr Hodge is now with the University of Louisville.

Arch Dermatol. 1976;112(11):1582-1588. doi:10.1001/archderm.1976.01630350056015

• A 21-year-old woman with eventually fatal malignant atrophic papulosis (Degos disease) was treated primarily with the fibrinolytic agents phenformin hydrochloride and ethylestrenol. In spite of therapy, primarily central nervous system manifestations led to the patient's death.

(Arch Dermatol 112:1582-1588, 1976)