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November 1976

Safety of Long-Term Tetracycline Therapy for Acne

Arch Dermatol. 1976;112(11):1603-1605. doi:10.1001/archderm.1976.01630350071017

• Results of blood chemistry studies using an automated multiple analysis system and blood cell counts for 325 patients receiving long-term low-dosage tetracycline hydrochloride therapy continuously for three years or longer revealed minimal changes in all but one patient. This patient developed a transient hyperbilirubinemia with mild jaundice while taking 500 mg of tetracycline daily.

(Arch Dermatol 112:1603-1605, 1976)

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