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November 1976

Pharmacokinetics of Salicylic Acid-Reply

Arch Dermatol. 1976;112(11):1610. doi:10.1001/archderm.1976.01630350076021

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—The comments of Cooper et al regarding our article "Percutaneous Absorption of Salicylic Acid" are appreciated. Unfortunately, I think they are attempting to derive more information from our data than the study was designed to provide. We made no attempt to carefully study the pharmacokinetics of salicylic acid absorption through normal or psoriatic epidermis. The purpose of the serum salicylate levels was to determine if daily treatment would lead to accumulation and not to evaluate peak concentrations or bioavailability. While it is true that serum levels in excess of 5 mg/100 ml may have occurred before or following our fivehour samples, they could never have been much in excess of this value, and certainly never approach toxic concentration.

We made no attempt to rigidly control the quantity of gel applied or to accurately assess the activity and area involved by psoriasis because this was not necessary for the study and

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