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December 1976

Psoriatic Angiogenic Factor: Evidence for Its Existence

Author Affiliations

Brooklyn, NY

Arch Dermatol. 1976;112(12):1789. doi:10.1001/archderm.1976.01630370069018

To the Editor.—  Folkman1 suggested the existence of an angiogenic factor in psoriasis. This concept was predicated on the similarity between psoriasis and tumors.Tumor angiogenic factor (TAF) had first been described by Folkman et al2 as the results of experiments with tissue culture. Subsequently, in animal experiments, Wolf and Harrison3 showed the existence of an epidermal angiogenic factor similar to TAF.Rapp et al4 and Glickman et al5 studied the evolution of vascular changes in induced and naturally occurring inflammation in the skin by means of the technique of capillary microscopy. Several stages in the inflammatory process, as reflected by the microvessels in the living human skin were described. These included (1) vasodilation: (2) vascular damage, characterized by the development of microaneurysms and extravasation of red blood cells; (3) proliferation, characterized by the appearance of arborization patterns at the terminal capillary loops, increasing the