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December 1976

Topically Applied Griseofulvin-Reply

Author Affiliations

San Francisco

Arch Dermatol. 1976;112(12):1790-1791. doi:10.1001/archderm.1976.01630370069020

In Reply.—  I am glad to know that the griseofulvin paradox has caught someone else's attention, but Dr Otani's suggestion is highly speculative. First, the early suggestions that griseofulvin has substantial antiinflammatory activity have not generally held up in clinical practice. When griseofulvin was evaluated for antiinflammatory activity in man by a croton-oil test used to study corticosteroids, we found the drug had no measurable activity in man.1 However, its effect on disaggregating microtubules2 may account for some of its effect on cell movement into lesions and for the antimitotic activity of griseofulvin. Second, although griseofulvin has antimitotic activity, it has not been demonstrated that topical application will produce such an effect. Furthermore, it is my understanding that griseofulvin's effect on fungi occurs not because of its antimitotic activity, but rather through an effect on cell-wall synthesis. In any event, the proposal made is one of several possibilities