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January 1977

Effects of Oral Zinc and Vitamin A in Acne

Author Affiliations

From the Department of Dermatology (Drs Michaëlsson, Juhlin, and Vahlquist) and Clinical Research II (Dr Vahlquist), Uppsala University Hospital, Uppsala, Sweden.

Arch Dermatol. 1977;113(1):31-36. doi:10.1001/archderm.1977.01640010033003

• The effects of oral zinc sulfate (corresponding to 135 mg of zinc daily) alone and in combination with vitamin A (300,000 international units) daily on acne lesions have been compared with those of vitamin A alone and of a placebo. The number of comedones, papules, pustules, and infiltrates were counted at each visit. After four weeks, there was a significant decrease in the number of papules, pustules, and infiltrates in the zinc-treated groups. The effect of zinc plus vitamin A was not better than zinc alone. After 12 weeks of treatment, the mean acne score had decreased from 100% to 15%. The mechanism for the effect of zinc therapy in acne, to our knowledge, is not presently known.

(Arch Dermatol 113-31-36, 1977)

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