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January 1977

Keratoacanthoma Centrifugum Marginatum

Author Affiliations

Padua, Italy

Arch Dermatol. 1977;113(1):110. doi:10.1001/archderm.1977.01640010112026

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To the Editor.—  In their article in the Archives (111:1024-1026, 1975), Weedon and Barnett reported a particularly large variant of keratoacanthoma centrifugum marginatum. We have recently observed a strikingly similar case.

Report of a Case.—  A 64-year-old woman was first treated by a country physician in January 1974 for a 2-cm keratotic noduleFig 1.—Lesion right calf showing central healing. Inset shows advancing edge in greater detail.Fig 2.—Advancing edge with distinctive epithelial infolding (hematoxylin eosin, original magnification × 10). on the front of her right calf. The patient was first examined in, and subsequently admitted to, our clinic in February 1975, when she had an extensive lesion, 20 × 15 cm, on the front of her right calf extending to both the medial and the lateral sides (Fig 1). It had a "serpiginous outline with an elevated rolled advancing edge, and there was central healing present." A biopsy confirmed

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