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February 1977

Glutaraldehyde (Pentanedial) Allergic Contact Dermatitis: Usage Test on Sole and Antecubital Fossa: Regional Variations in Response

Author Affiliations

From the Department of Dermatology, University of California School of Medicine, San Francisco. Dr Prystowsky is now with the Department of Dermatology Research, Letterman Army Institute of Research, Presidio of San Francisco.

Arch Dermatol. 1977;113(2):170-171. doi:10.1001/archderm.1977.01640020042006

• Glutaraldehyde (pentanedial) is an effective topical therapeutic agent for patients with hyperhidrosis of the soles. A usage test was performed on the soles and antecubital fossae of six previously documented glutaraldehyde-sensitive subjects. All had negative usage test reactions to 25% glutaraldehyde on the soles. But when tested on the antecubital fossae with 2.5% glutaraldehyde, they developed a severe dermatitis within 48 hours. These data demonstrate a striking variation by which glutaraldehyde-sensitive patients tolerate or react to its use in two diverse anatomic sites.

(Arch Dermatol 113:170-171, 1977)