• Glutaraldehyde (pentanedial) is an effective topical therapeutic agent for patients with hyperhidrosis of the soles. A usage test was performed on the soles and antecubital fossae of six previously documented glutaraldehyde-sensitive subjects. All had negative usage test reactions to 25% glutaraldehyde on the soles. But when tested on the antecubital fossae with 2.5% glutaraldehyde, they developed a severe dermatitis within 48 hours. These data demonstrate a striking variation by which glutaraldehyde-sensitive patients tolerate or react to its use in two diverse anatomic sites.
(Arch Dermatol 113:170-171, 1977)
Maibach HI, Prystowsky SD. Glutaraldehyde (Pentanedial) Allergic Contact DermatitisUsage Test on Sole and Antecubital Fossa: Regional Variations in Response. Arch Dermatol. 1977;113(2):170–171. doi:10.1001/archderm.1977.01640020042006