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February 1977

Failure of Fresh Plasma in Leiner Disease

Author Affiliations



Arch Dermatol. 1977;113(2):233-234. doi:10.1001/archderm.1977.01640020105019

To the Editor.—  A 2-month-old infant had a generalized seborrhea-like eruption, respiratory distress, and failure to gain weight since birth. Birth weight was 3,224 gm (7 lb 2 oz) and weight upon admission was 2,995 gm (6 lb 1 oz). Family history was significant in that a similar eruption, in addition to respiratory distress, developed in a sibling. At the age of 6 months, that sibling had respiratory failure requiring constant oxygen and respirator care and died at 16 months of age, of a Gram-negative septicemia.The infant was covered with erythematous papules topped by greasy scales that involved the entire body, sparing the palms and soles. He had respiratory distress; blood gas determinations showed hypoxia, requiring oxygen administration. A chest x-ray film revealed bilateral pulmonary infiltrates. A WBC count was elevated (15,300/cu mm), with 80% neutrophils. Immunoglobulins were normal and the child was blood type O-positive. E rosette-forming cells

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