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February 1977

Erythema Nodosum Leprosum

Author Affiliations

Amina Meneses Bogota, Colombia

Arch Dermatol. 1977;113(2):234. doi:10.1001/archderm.1977.01640020106022

To the Editor.—  The publication of a work by Rea and Levan (111:1575, 1975) in which they discuss the pathogenesis of erythema nodosum leprosum and make a broad bibliographical review in which we couldn't find any reference to findings similar to ours, moves us to send a preliminary communication on the results of the work that we are performing on this subject.Since it has been considered that the most probable cause of erythema nodosum leprosum is a type III immunological response (Arthus phenomenon), and IgG deposits in the walls of vessels have been described,1,2 we wanted to know which of the four known IgG subclasses were responsible for the phenomenon. For this purpose, using direct inmunofluorescence, we made studies in 19 patients utilizing fluoresceinated antisera against IgG1, IgG2, IgG3, IgG4, IgM, IgD, IgA, and C3. In 14 of the 19 patients we found C3 deposits in the walls

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