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February 1977

Ophthalmic Sulfonamide-Induced Stevens-Johnson Syndrome

Arch Dermatol. 1977;113(2):235-236. doi:10.1001/archderm.1977.01640020107025

To the Editor.—  A case of StevensJohnson syndrome from the ophthalmic use of sulfacetamide sodium was presented by Gottschalk and Stone (112:513,1976) and believed by them to be the first such reported case.I wish to submit a brief and belated report of a case of Stevens-Johnson syndrome that occurred in 1970 and was apparently due to the combined effect of an intermediate-dosage sulfonamide and sodium sulfacetamide. An ophthalmologist requested an emergency consultation in his office for a patient whom he was examining for the first time and who was in pain and incapable of walking because of his general condition and a "painful condition affecting his eyes."

Report of a Case.—  The patient, a 73-year-old man, was obviously having a toxic reaction. His daughter stated that her father never reacted adversely to any orally or parenterally administered or topically applied medication. In January 1970 the patient had been operated