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April 1977

Phenytoin-Induced Pseudolymphoma SyndromeAn Immunologic Study

Author Affiliations


From the Department of Medicine, Wilford Hall USAF Medical Center, Lackland Air Force Base, San Antonio, Tex. Maj Charlesworth is now with the Keesler USAF Medical Center, Biloxi, Miss.

Arch Dermatol. 1977;113(4):477-480. doi:10.1001/archderm.1977.01640040085013

• In vitro and in vivo immunologic studies were performed on a 28-year-old woman with phenytoin sodium-induced pseudolymphoma syndrome. During the acute phase of the syndrome, the patient appeared immunologically depressed. Six months after resolution of lymphadenopathy, repeat studies demonstrated a return to immunologic competence. In vitro studies of the patient's lymphocytes when incubated with phenytoin failed to indicate a delayed hypersensitivity reaction to the drug. These findings suggest that the patient developed a clinical lymphatic proliferation at a time when she was immunologically depressed. This may result in an increased chance of a mutant malignant clone developing at a time when the immunosurveillance system is impaired and explains why a rare patient with this syndrome may develop a frank malignant lymphoma.

(Arch Dermatol 113:477-480, 1977)