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May 1977

Effect of Sodium Salicylate and Indomethacin on Methotrexate-Serum Albumin Binding

Author Affiliations

From the Dermatology Service, Miami Veterans Administration Hospital and the Department of Dermatology, University of Miami School of Medicine, Miami.

Arch Dermatol. 1977;113(5):588-591. doi:10.1001/archderm.1977.01640050048003

• Approximately 60% of methotrexate in serum is protein bound and this binding occurs primarily to serum albumin. The fraction of methotrexate bound remains relatively constant despite changes in free methotrexate concentrations over the range observed clinically.

Indomethacin did not influence methotrexate-albumin binding, but salicylate in therapeutic concentrations produced a 20% to 60% decrease in binding. The clinical significance of these findings for patients requiring concomitant methotrexate and salicylate is discussed.

(Arch Dermatol 113:588-591, 1977)

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