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May 1977

Familial Lupus: Spectrum of Disease in One Family

Arch Dermatol. 1977;113(5):685. doi:10.1001/archderm.1977.01640050145032

To the Editor.—  In a recent study on lupus erythematosus (LE), Prystowsky and Gilliam1 separated their patients into the following three groups: a group of patients with LE limited to the skin; a group with active discoid lesions plus visceral involvement; and a group with proliferative glomerulonephritis. We found this particularly interesting for we were observing at that time a case of familial lupus in which the three probands corresponded to these three distinct groupings.

Report of Cases.— 

Case 1.—  A 26-year-old woman was seen in August 1975, with atrophic, tender, hypopigmented areas on her palms and soles, breasts, thighs, and scalp that were accompanied with arthralgia, morning stiffness, recent weight loss, and Raynaud phenomenon. The patient appeared ill and was hospitalized. A test for antinuclear antibody (ANA) was positive in titer of 1:1,280 and was reported as 3+ shaggy. The anti-DNA was less than 1:10 μg/ml. Lupus erythematosus

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