• Observations surrounding the clinical manifestations and pathological studies of a neonate who died at 9 weeks of age, indicate that distinctive cutaneous, histopathologic, and ultrastructural findings occur when graft-vs-host reaction (GVHR) complicates combined immune deficiency syndrome (CIDS). The prominence and specificity of the epidermal lesions, particularly a necrotic cell that occurs in association with satellite lymphocytes ("satellite cell necrosis" (SCN)), lead us to recommend that a cutaneous biopsy be performed to facilitate an early definitive diagnosis. Dermatologists can recognize GVHR at the bedside and establish the diagnosis with the pathological findings obtained from the skin biopsy.
(Arch Dermatol 113:806-812, 1977)
Grogan TM, Odom RB, Burgess JH. Graft-vs-Host Reaction. Arch Dermatol. 1977;113(6):806–812. doi:10.1001/archderm.1977.01640060102014
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: