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June 1977

Congenital Disseminate Organoid Tumors

Arch Dermatol. 1977;113(6):851. doi:10.1001/archderm.1977.01640060147031

To the Editor.—  We recently had the opportunity to observe a newborn infant with distinctive generalized organoid tumors that appeared to represent poorly differentiated attempts at hair formation.

Report of a Case.—  A 3,416-gm full-term male infant was born with milia-like papules present everywhere on the body surface except the palms and soles. Normal hair was present in normal concentration and distribution. There were metatarsus varus of the left ankle and pectus excavatum. The rest of the physical examination was normal. At five days after birth the infant experienced respiratory distress followed by low-grade fever and diarrhea. Progressive cardiopulmonary distressGroups of follicular units in dermis (× 30). ended life at the 44th day. Values for all urine, stool, blood, spinal fluid, and skin cultures were negative. At autopsy, endocardial fibroelastosis in the outflow tract of the heart was found. Extensive pleomorphic inflammatory cell infiltrates were present in the media

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