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To the Editor.—
As I read the "Comment" section of the case report of Drs Campo and McDonald, which was entitled "Treatment of Acrodermatitis Enteropathica With Zinc Sulfate" (Arch Dermatol 112:687-689, 1976), an interesting thought occurred to me. The physicians point out that among many other treatments, penicillamines have been used for treatment. That being the case, and if their theory is correct, the penicillamine-treated babies should have gotten worse, since penicillamine is a nonselective chelator and it would, therefore, surely have chelated the zinc in an already presumably zincdeficient baby. I hope that we hear from the penicillamine-users as to whether their patients did get worse, because it would be excellent indirect evidence of the correctness of the theory of Drs Campo and McDonald.In my own experience, there was a child with Wilson's disease who, on long-term penicillamine therapy, developed a very severe dermatitis that responded very nicely
Ward AN. Treatment With Penicillamines. Arch Dermatol. 1977;113(7):983–984. doi:10.1001/archderm.1977.01640070117026
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