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August 1977

Defective Monocyte Chemotaxis in Mycosis Fungoides

Arch Dermatol. 1977;113(8):1055-1057. doi:10.1001/archderm.1977.01640080057005

• Monocyte-macrophage function was studied in 14 patients with histologically confirmed mycosis fungoides. Three component parts of the monocyte-macrophage system were examined. Monocyte bacterial phagocytosis and bacterial killing were normal. However, a defect in directional mobility (chemotaxis) was found in patients with mycosis fungoides (P <.0025) when compared to 35 healthy controls. Defective chemotaxis was present regardless of disease stage or therapy. This defect in monocyte chemotaxis represents a previously unrecognized immune deficiency and may help explain the frequent infections found in patients with mycosis fungoides.

(Arch Dermatol 113:1055-1057, 1977)