To the Editor.—
Banded structure in cellular blue nevus presented by Bhawan and Edelstein in the Archives (112:1176-1177, 1976) warrants further comment.Extensive investigation with the electron microscope on the relationship between blue nevus cells and nerves led me to believe that the blue nevus cells proliferate outside of the perineurium and do not invade the endoneurium. Even in the most tiny myelinated and unmyelinated fibers, devoid of perineurial sheath, the "fundamental architectural unit"1 is respected, and degeneration of Schwann cells and axons takes place very late if ever. The picture published by Bhawan and Edelstein stresses this, and, as far as it is found repeatedly, represents an objective argument against the neural origin of blue nevus.The "striated body," is quite common in normal tissues with immature collagen fibers (the so-called reticulin fibers) and especially in the central and peripheral nervous structures.1 It is present too in
Bourlond A. Bands in Cellular Blue Nevus. Arch Dermatol. 1977;113(8):1129–1130. doi:10.1001/archderm.1977.01640080131032
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