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August 1977

Cantharidin Treatment of Warts at Home

Arch Dermatol. 1977;113(8):1134. doi:10.1001/archderm.1977.01640080136040

To the Editor.—  Cantharidin treatment of warts has become increasingly popular since first suggested by Epstein and Kligman in 1958.1 The presently available commercial preparation of cantharidin carries a package insert suggesting application by the physician and the use of occlusive tape dressing to enhance the drug's blistering effect. Because the proper application of small pieces of occluding tape can be time-consuming, and because office treatment usually requires one or more return office visits, we decided to investigate the use of cantharidin as a self-applied, home treatment for warts.The cantharidin was supplied as a 0.7% solution in acetone-flexible collodion in specially sized, 2.5-ml applicator bottles for ease of self-application. A standard (green) food color was added to simplify the process of self-application. The patients (or their parents) were told to apply a small amount of the colored solution directly to the wart, allow it to dry, and then

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