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September 1977

An Unusual Contact Photosensitizing Reaction

Author Affiliations

Highland Park, Ill

Arch Dermatol. 1977;113(9):1297. doi:10.1001/archderm.1977.01640090145034

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To the Editor.—  The increase in the patch testing of materials and products by companies, individual testing laboratories, and physicians may uncover unusual reactions.The study of the photosensitizing potential of a yet unmarketed surgical scrub was undertaken. The total product was applied to the back of volunteers as was the vehicle control. Test materials were applied daily for five days (excluding weekends) for two weeks. On Tuesday and Thursday of each week, the patch areas were left uncovered for 30 minutes after application of the test materials. The test sites were exposed then to twice the subjects' minimal erythema dose (MED) using an ultraviolet lamp (Atlas xenon arc). Patches (Parke-Davis Readi-Band Clear Plastic Patches with nonwoven Webril centers) were used.On Wednesday of week 2 (ten days after starting the test), one subject reacted on every test and control site. Ultraviolet irradiation had been administered 24 hours earlier. After

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