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Reactions to drugs may clinically simulate almost every dermatitis and may elicit histological patterns similar to that of almost every inflammatory reaction in the skin. Among the most common are the lichenoid, acneiform, and urticarial. Furthermore, drugs are among the most common causes of bullous dermatitides, such as erythema multiforme and toxic epidermal necrolysis, and of allergic vasculitis. The fixed drug eruption is evoked by drugs.In our experience, however, a drug has yet to provoke histological changes such as those of herpes gestationis and for that reason that condition was not included among our differential diagnoses. Oral contraceptives, however, may exacerbate herpes gestationis as in case 1. We think that, apart from bullous pemphigoid, the histological features of herpes gestationis are rather specific and not imitated by any drug eruption.
Hertz K, Katz S, Maize J, Ackerman AB. Herpes Gestationis-Reply. Arch Dermatol. 1977;113(9):1299. doi:10.1001/archderm.1977.01640090147039
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