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September 1977

Mechanisms of Topical Corticosteroid Activity

Author Affiliations

San Francisco

Arch Dermatol. 1977;113(9):1311. doi:10.1001/archderm.1977.01640090159060

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There have been several pertinent reviews of corticosteroids recently. The first by D. Azarnoff (Steroid Therapy, Philadelphia, WB Saunders Co, 1975) covers systemic and topical applications whereas the second in Dermatologica (152, suppl 1, 1976) discusses topical activity. The present summary of a symposium on mechanisms of topical steroid activity supplements material presented in the previous two reviews. With these three books, the student of corticosteroids receives a broad view of the problems that have been solved and those that remain to be solved.

This volume has several new research contributions. These include a study of the effect of corticosteroids on skin fibrinolytic activity (Tebs and Cunliff), the fine points of the effect of corticoids on skin pulses (Tune), and several papers attempting to explain their effect on epidermal cell kinetics. A clear statement on the negative effect of corticosteroids on melanin pigmentation in the guinea pig (S. Bleehan) and several papers discussing the putative anti-inflammatory roles of these compounds are valuable.

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