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October 1977

Topical Mechlorethamine: Cutaneous Changes in Patients With Mycosis Fungoides After Its Administration

Author Affiliations

From the Dermatology Service, Veterans Administration Hospital, Palo Alto, and the Department of Dermatology, Stanford University Medical Center, Calif.

Arch Dermatol. 1977;113(10):1387-1389. doi:10.1001/archderm.1977.01640100065010

• Six patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride for periods of two to four years. Clinical and histological studies for radiomimetic and radiodermatitis-like effects failed to demonstrate any abnormalities. The only observed changes were generalized hyperpigmentation of the skin and melanin-containing melanophages in the papillary dermis. We consider that the long-term use of topical mechlorethamine may be a safe form of therapy, but that a continuous indefinite follow-up of patients on this medication should be mandatory.

(Arch Dermatol 113:1387-1389, 1977)

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