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October 1977

Topical Mechlorethamine: Cutaneous Changes in Patients With Mycosis Fungoides After Its Administration

Arch Dermatol. 1977;113(10):1387-1389. doi:10.1001/archderm.1977.01640100065010

• Six patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride for periods of two to four years. Clinical and histological studies for radiomimetic and radiodermatitis-like effects failed to demonstrate any abnormalities. The only observed changes were generalized hyperpigmentation of the skin and melanin-containing melanophages in the papillary dermis. We consider that the long-term use of topical mechlorethamine may be a safe form of therapy, but that a continuous indefinite follow-up of patients on this medication should be mandatory.

(Arch Dermatol 113:1387-1389, 1977)