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October 1977

Scleroderma-like Changes in Chronic Graft vs Host Disease

Arch Dermatol. 1977;113(10):1424-1428. doi:10.1001/archderm.1977.01640100102020

† A case of chronic graft vs host disease had scleroderma-like skin changes. Clinical progression was from poikiloderma to scleroderma, and histopathological changes and results of direct immunofluorescence were noted. It is probable that both cell-mediated (T-cell) and humoral (B-cell) mechanisms contribute to the pathogenesis of the graft vs host reaction.

(Arch Dermatol 113:1424-1428, 1977)