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October 1977

Myeloid Metaplasia of the Skin in Two Patients Suffering From Primary Myelofibrosis

Author Affiliations

Lyon, France

Arch Dermatol. 1977;113(10):1459. doi:10.1001/archderm.1977.01640100137038

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To the Editor.—  KUO et al reported a case of extramedullary cutaneous hematopoiesis in a 66-year-old patient suffering from myelofibrosis (Archives 112:1302-1303, 1976). We have had occasion to make two observations on this specific skin disorder.

Report of Cases.—Case 1.—  The first patient, a 62-year-old man, had highly pruriginous, diffuse cutaneous infiltration with accentuated skin folds that was accompanied by mild erythema, which prompted us to perform a biopsy. This revealed a superficial dermic infiltrate composed of eosinophilic promyelocytes and myelocytes that evolved toward polyneutrophilic nuclear cells. The neutrophilic participation was less noticeable. This patient died 1½ years later during an infectious episode with serious, irreducible anemia.

Case 2.—  In the second patient, a 68-year-old woman, the pruritis, which was severe and widespread, was associated with erythematous, papular lesions scattered all over the body. On the thighs, the skin was thickened and pachydermic. Histological examination of the skin

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