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October 1977

Treatment of Herpes Simplex Infections

Author Affiliations

Providence, RI

Pawtucket, RI

Arch Dermatol. 1977;113(10):1463. doi:10.1001/archderm.1977.01640100141048

To the Editor.—  In a recent article, Dr Bierman (Archives 112:1410-1415, 1976) reported 38 cases of recurrent herpes progenitalis that were treated by repeated bacillus Calmette-Guérin (BCG) inoculations. No substantial benefit was demonstrated as compared with that obtained with other homologous or heterologous antigens or with placebos.In his review of herpesvirus hominis (HVH) immunoprophylaxis, reference was made to our investigations of both heterologous and homologous antigens.1,2 We would like to call attention to the author's quotation from our article to the effect that "a heat-inactivated type 1 HVH vaccine grown on rabbit kidney (Eli Lilly) was partially effective in reducing the frequency and severity of herpes labialis." Unfortunately, Dr Bierman failed to mention in the text (although it was indicated in Table 3) the important finding that our control solution was just as effective as the active one. to conclude that the benefit observed was entirely attributable to

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