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November 1977

Vitiligo and Juvenile Diabetes Mellitus

Author Affiliations

From the Department of Medicine (Drs Macaron, Winter, Traisman, and Green) and Dermatology (Dr Lasser), Northwestern University Medical School; and the Department of Dermatology, Children's Memorial Hospital (Dr Lasser). Dr Macaron is now with Edgewater Hospital and the Department of Medicine, Chicago Medical School, and Dr Kahan is now with the Department of Surgery, University of Texas Health Science Center, Houston.

Arch Dermatol. 1977;113(11):1515-1517. doi:10.1001/archderm.1977.01640110035002

• Five juvenile diabetics had vitiligo. In two children, the vitiligo preceded the onset of diabetes. Four of the five patients had thyroid, adrenal, or gastric antibodies or a combination of these. In three children HLA-B8 antigens were detected, and one additional patient had HLA-Bw15. Of eight nondiabetic children with vitiligo, one had abnormal glucose tolerance. To the evidence supporting an autoimmune form of diabetes mellitus we add another observation: the association of insulindependent diabetes and childhood vitiligo.

(Arch Dermatol 113:1515-1517, 1977)