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November 1977

Benign Mucous Membrane Pemphigoid: Response to Therapy With Cyclophosphamide

Author Affiliations

From the Department of Dermatology, Emory University School of Medicine, Atlanta.

Arch Dermatol. 1977;113(11):1598-1599. doi:10.1001/archderm.1977.01640110118022

Benign mucous membrane pemphigoid, also called cicatricial pemphigoid, is a chronic vesiculobullous disease of the mucosa and skin that results in permanent scarring of the affected areas, often causing blindness. Reports of treatment for this disorder have been scanty and quite variable in presentation. To our knowledge, this is the first case report of an initially recalcitrant patient treated successfully with cyclophosphamide.

Report of a Case  A 49-year-old man was in good health until June 1975 when he noted injection of the right conjunctiva accompanied by photophobia. The diagnosis was staphylococcal keratoconjunctivitis, and he was treated accordingly with antibiotics and topical steroid combinations with minimal response and progression to the left eye in September of 1975. Several months later an

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