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November 1977

An Unusual Variant of Darier's Disease: A Therapeutic Suggestion

Author Affiliations

Los Angeles

Arch Dermatol. 1977;113(11):1615. doi:10.1001/archderm.1977.01640110135047

To the Editor.—  In the March 1977 issue of the Archives (113:374), Dr Dolezal describes a severe case of the cornifying variant of Darier's disease that was widespread distribution, with painful, malodorous, and secondarily infected vegetations on the lower legs and feet. The article is illustrated with four color photographs that emphasize the patient's tragic plight. The patient was lost to follow-up for 11 years, but when seen again, the patient's condition had not changed. There was no mention of therapy on either occasion, except that the secondary infection had been cleared up with "tetracycline and acetic acid compresses" during his initial visits. When seen 11 years later, the malodorous infection was again present.We reported the successful control of keratosis follicularis (Darier's disease) with the use of a combination of vitamins A and E (Arch Dermatol 106:909-910, 1972). Our patient was a 26-year-old man who had had a severe,

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