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December 1977

Pemphigus-like Antibodies in Bullous Pemphigoid

Author Affiliations

From the Cutaneous Immunopathology Unit (Drs Heine and Jordon) and the Department of Dermatology (Dr Jordon), Mayo Medical School and Foundation, Rochester, Minn; and the Springfield (Ill) Clinic (Dr Kumar).

Arch Dermatol. 1977;113(12):1693-1695. doi:10.1001/archderm.1977.01640120061010

• A patient had clinical, histopathologic, and direct immunofluorescent findings compatible with a diagnosis of bullous pemphigoid. In addition, the patient's serum contained pemphigus-like antibodies with different antigenic specificities than true pemphigus antibodies. Absorption of the patient's serum with AB substance failed to block the intercellular substance staining but allowed the demonstration of a basement membrane zone reactive antibody as well. Atypical cases such as this should not cast doubt on the usefulness of immunofluorescence in the diagnosis of bullous skin diseases.

(Arch Dermatol 113:1693-1695, 1977)

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