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December 1977

HLA-B12 in Alopecia Areata

Author Affiliations

From the Department of Dermatology, University Central Hospital (Drs Kianto, Reunala, Karvonen, and Lassus), and the Finnish Red Cross Blood Transfusion Service (Dr Tiilikainen), Helsinki.

Arch Dermatol. 1977;113(12):1716. doi:10.1001/archderm.1977.01640120084017

Alopecia areata is a disease of unknown origin with some degree of hereditary transmission. We have analyzed the HLA antigens1 in 47 unrelated Finnish patients with alopecia areata.

Subjects  The series comprised of 22 women and seven men with alopecia areata. These patients had patchy alopecia of the scalp. Six men and eight women had alopecia totalis, ie, total hair loss of the scalp. Two men and two women had alopecia universalis, ie, hair loss of the entire body.

Results  The HLA phenotype frequencies in the 47 patients and in a Finnish control population2 are shown in Table 1. The increase of HLA-B12 was significant (χ2 = 15.67, P = .000075, P = .0018 after the correction for the 24 HLA specificities, relative risk = 3.59).In the 29 patients with patchy alopecia areata, the association with HLA-B12 was even stronger (χ2 = 20.80, P = .0000051, P = .00012 after correction, relative risk