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December 1977

Immunotherapy for Leprosy

Arch Dermatol. 1977;113(12):1731. doi:10.1001/archderm.1977.01640120099033

To the Editor.—  In the March 1977 issue of the Archives (113:345-352), Drs Rea and Levan reviewed the current concepts in the immunology of leprosy. They noted the work of Lim et al1 with respect to the treatment of leprosy patients with intravenous infusions of leukocytes from normal persons. Rea and Levan stated, "Lim et al reported improvement in lepromatous patients associated with the administration of deliberately mismatched leukocytes. To our knowledge, the confirmatory studies have not been reported."In the article by Lim et al,1 the patients who were treated were three lepromatous patients and one tuberculoid patient. The authors reported remission of the patients' leprosy as measured by the following three measures: clinical, histologic, and bacteriologic.Rea and Levan used the term "deliberately mismatched leukocytes" in referring to the whole WBC infusions. This may imply to the reader a major incompatibility with possibly ABO blood types. In the

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