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December 1977

Dimethylglyoxime Stick Test for Easier Detection of Nickel

Arch Dermatol. 1977;113(12):1734. doi:10.1001/archderm.1977.01640120102043

To the Editor.—  Nickel is everywhere. Consequently, the nickel-sensitive patient must constantly be on the alert since exposure to this metal could inflict a pruritic, eczematous wound. But how can the nickel-sensitive individual know exactly what he can or cannot touch? We have found that a relatively simple modification of the dimethylglyoxime spot test can greatly increase its usefulness and provide information that will be of help in preventing inadvertent reexposure to nickel.The dimethylglyoxime test for detection of nickel, first described by Fleigl1 and modified by Fisher,2 consists of adding a few drops of 1% dimethylglyoxime in alcoholic solution and a few drops of 10% ammonium hydroxide solution to a test object and observing for the presence of a red precipitate. In our modification of this procedure, a few drops of dimethylglyoxime and ammonium hydroxide are successively placed on a cotton-tipped applicator, and the cotton tip is