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January 1978

A Mechanobullous Disease of the Newborn: Bart's Syndrome

Author Affiliations

From the Department of Dermatology, University of California School of Medicine, San Francisco. Dr Smith is now in private practice in Louisville.

Arch Dermatol. 1978;114(1):81-84. doi:10.1001/archderm.1978.01640130045013

• A patient had a unique mechanobullous disease (Bart's syndrome). The characteristic congenital localized skin defects, trauma-induced erosions, and nail deformities are present. The inheritance pattern appears to be autosomal dominant but, as in this report, isolated cases have been recognized.

In a review of the other mechanobullous diseases, Bart's syndrome appears to present a distinctive clinical picture and course and has a favorable prognosis. The progressive spontaneous improvement emphasizes the importance of early recognition and conservative treatment.

(Arch Dermatol 114:81-84, 1978)