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January 1978

Treatment of Hallopeau's Acrodermatitis With Topical Mechlorethamine

Author Affiliations

Rotterdam, Netherlands

Arch Dermatol. 1978;114(1):129. doi:10.1001/archderm.1978.01640130087038

To the Editor.—  The therapy for Hallopeau's acrodermatitis (continua, perstans), which includes the use of common topical antipsoriatic agents like tar, cignolin, and corticosteroids, is mentioned in literature, but the extreme resistance of the disease to any therapy is well known.The systemic use of cytostatic agents (methotrexate) has been described with good results in this disease, but it carries all the inevitable risks of a long-term treatment.1 Topical use of methotrexate soaks under occlusion, which have been used alternately with betamethasone valerate, has been found to have beneficial results in the treatment of relapsing pustular eruption of the hands and feet.2We could not find a report of the topical use of a cytostatic agent in the treatment of Hallopeau's acrodermatitis. Topical application of mechlorethamine hydrochloride (a nitrogen mustard) has been found to be useful in psoriasis.3 We decided to treat a patient with Hallopeau's acrodermatitis with

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