• The familial occurrence of chronic polymorphous light eruptions (CPLE) was investigated by a thorough interrogation of 91 CPLE patients. Fifty-one of these were aware of the presence of one to five familial cases, a number of which were evaluated and confirmed as CPLE. The secondary cases were usually morphologically similar to the primary case, but notable exceptions were occasionally recorded. The genealogical data pointed toward an autosomal dominant mode of inheritance of the CPLE trait, with a reduced penetrance. In the sibships of 80 persons with presumed or confirmed CPLE, the rate of penetrance was estimated to be 52%. The atopic trait appeared to be a factor promoting the manifestation of the latent CPLE trait.
(Arch Dermatol 114:188-190, 1978)
Jansen CT. Heredity of Chronic Polymorphous Light Eruptions. Arch Dermatol. 1978;114(2):188–190. doi:10.1001/archderm.1978.01640140006002
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