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February 1978

Macroglobulinemia Cutis

Author Affiliations

From the Sections of Dermatology, Department of Medicine (Drs Tichenor and Rau) and Pathology (Dr Mantz), University of Kansas Medical Center, Kansas City.

Arch Dermatol. 1978;114(2):280-281. doi:10.1001/archderm.1978.01640140090024

Abnormal lymphoid cell infiltration, amyloid, and macroglobulin depositions have all been described in patients with Waldenström's macroglobulinemia. The liver, lymph nodes, spleen, kidneys, bone marrow, synovia, skeletal muscle, gastrointestinal tract, CNS, lungs, and skin have all been reported to be involved by these processes.1,2 The purpose of this report is to describe a patient who had papular skin lesions of the knees that histologically resembled lichen amyloidosus, but on further study were found to be deposits of IgM.

Report of a Case  A 72-year-old man was initially seen at University of Kansas Medical Center in August 1970 with a chief complaint of "numbness of the legs" of three years' duration and a 20-lb weight loss. Results of laboratory studies showed a serum viscosity of 1.80, ESR of 25 mm/hr, a positive Sia water test, and an elevated gamma fraction without peaks on protein electrophoresis. Immunoglobulin assay showed an aberrant

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