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February 1978

Malignant Acanthosis Nigricans

Author Affiliations

From the Departments of Dermatology (Dr Leviatan), Oncology (Drs Weshler and Walach), and Orthopaedics (Dr Lowe), Hadassah-University Hospital, Jerusalem.

Arch Dermatol. 1978;114(2):281-282. doi:10.1001/archderm.1978.01640140091025

A woman had had acanthosis nigricans (AN) for six years before a diagnosis of carcinoma of the stomach was made. During the six months just prior to the discovery of the carcinoma, the AN had become severe, and, after chemotherapy and radiotherapy for the tumor, the AN showed regression.

Report of a Case  A 67-year-old woman was admitted to the hospital because of difficulty in swallowing liquid food, epigastric pain, general weakness, and loss of 8 kg of body weight during the last four months.Six years prior to admission, hyperpigmentation, small papillomas, and roughened skin were noted in the axillae, groins, and under the breasts. Similar lesions appeared six months before admission on the buccal mucosa and gums, and the skin lesions began to itch. A gastric ulcer of the lesser curvature had been diagnosed previously and treated with a diet. In 1968 a cholecystectomy was performed.On admission,

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