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February 1978

Pseudoxanthoma Elasticum

Arch Dermatol. 1978;114(2):288. doi:10.1001/archderm.1978.01640140096032

To the Editor.—  In describing techniques of autofluorescence, Sams1 refers to three types of fluorescence. There is specific immunologic staining, nonspecific staining, and autofluorescence. Autofluorescence occurs in many tissues including the skin.Fig 1.—Close-up of lesions on neck.Sams noted the autofluorescence of elastic fibers in dermis, and we have reported autofluorescence in epidermis corresponding to the location of melanin.2,3Specific immunologic staining has been used since Beutner et al4 in 1965 described the presence of specific autoantibodies in serums of patients with pemphigus. Little has been described on autofluorescence findings related to pathological skin conditions.We report a case of pseudoxanthoma elasticum in which autofluorescent findings highlight features of the skin pathology. Pseudoxanthoma elasticum is an autosomal recessive hereditary disease in which genetically abnormal elastic fibers tend to calcify in the skin, oral mucosa, and eyes. This patient, a 49-year-old woman, had characteristic lesions of a

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