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March 1978

Trichophytin Reactions in Children With Tinea Capitis

Author Affiliations

From the Department of Dermatology, State University of New York at Buffalo (Drs Rasmussen and Ahmed); Children's Hospital of Buffalo (Dr Rasmussen); and Buffalo General Hospital (Dr Ahmed), Buffalo, NY. Dr Ahmed is now with the Clinical Immunology Service, Department of Immunology and Microbiology, UCLA School of Medicine, Center for Health Sciences, Los Angeles.

Arch Dermatol. 1978;114(3):371-372. doi:10.1001/archderm.1978.01640150007002

Of 52 patients with proved Trichophyton tonsurans infection of the scalp, 16 had an inflammatory reaction to this infection (kerion), while the rest had only slight scaling and broken hairs (black dot ringworm). Each patient was tested with trichophytin antigen to determine whether cell-mediated immunity (CMI) was responsible for the differences in these different clinical presentations. Fifteen of 16 with kerion had a 48-hour reaction > 10 mm, while none of the 36 with noninflammatory (black dot) tinea capitis had a similar response. This suggests that the patient's immune response (CMI) may be responsible for kerion infections of the scalp and that therapy could be directed initially toward suppressing this reaction.

(Arch Dermatol 114:371-372, 1978)