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March 1978

Generalized Argyria: Clinicopathologic Features and Histochemical Studies

Author Affiliations

From the Dermatology Services, Veterans Administration Hospital, and the Department of Dermatology, University of Miami (Fla) School of Medicine.

Arch Dermatol. 1978;114(3):373-377. doi:10.1001/archderm.1978.01640150009003

• In three cases of generalized argyria, the degree of slate-gray cutaneous discoloration varied from barely perceptible to pronounced. Deposition of silver-containing granules in and around cutaneous adnexal structures was best seen with darkfield microscopy. Histochemical studies suggested that the granules consisted of silver sulfide. Indiscriminate use of currently available silver-containing medications can result in generalized argyria.

(Arch Dermatol 114:373-377, 1978)

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