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March 1978

Photochemotherapy of Psoriasis (PUVA) Without Specialized Equipment

Author Affiliations

From the Department of Dermatology (Dr Kligman), University of Pennsylvania School of Medicine, and the Dermatology Section (Dr Petrozzi), Veterans Administration Hospital, Philadelphia.

Arch Dermatol. 1978;114(3):387-390. doi:10.1001/archderm.1978.01640150023007

• High intensity long ultraviolet light (UV-A) systems along with oral methoxsalen (8-methoxypsoralen [8-MOP]) have been dramatically successful in clearing long-standing psoriasis. Since this equipment is beyond the reach of many dermatologists, we have examined alternate ways of achieving the benefits of PUVA photochemotherapy. A total of 24 patients with psoriasis have been treated with ordinary fluorescent blacklights in a conventional Zimmerman cabinet. Fourteen patients' conditions (58%) were cleared completely and the conditions of three (12%) were more than 80% improved. We used higher doses of 8-MOP, starting with 50 mg, and increased the dosage further in 15 cases. In five instances, 80-mg levels were given.

With certain modifications, it may be possible to attain satisfactory therapeutic results with ordinary equipment. Higher doses of 8-MOP may be necessary to compensate for the lower irradiance light source in some instances. However, widespread use of PUVA therapy cannot be recommended at this time until the longterm effects of this treatment become known.

(Arch Dermatol 114:387-390, 1978)