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March 1978

Uveitis, Poliosis, Hypomelanosis, and Alopecia in a Patient With Malignant Melanoma

Author Affiliations

From the Departments of Dermatology, Harvard Medical School (Drs Sober and Haynes) and Massachusetts General Hospital (Dr Sober); Melanoma Clinical Cooperative Group (Dr Sober); and Division of Dermatology, Department of Medicine, Peter Bent Brigham Hospital, Boston (Dr Haynes).

Arch Dermatol. 1978;114(3):439-441. doi:10.1001/archderm.1978.01640150075022

• Bilateral uveitis, poliosis, hypomelanosis, and alopecia (Vogt-Koyanagi-Harada syndrome) developed spontaneously in a 57-year-old woman following operation for metastatic malignant melanoma. She has been disease-free for 8½ years in spite of a highly unfavorable prognosis. Within the framework of current concepts of cell-mediated and humoral immunity in patients with malignant melanoma, activity of the host's immune system is postulated for the destruction of normal melanocytes in the skin, hair follicle, and uveal tract, as well as for the favorable outcome.

(Arch Dermatol 114:439-441, 1978)